Convergent synthesis Totally Explained

Everything about Convergent Synthesis totally explained

In chemistry a convergent synthesis is a strategy that aims to improve the efficiency of multi-step chemical synthesis. In linear synthesis the overall yield quickly drops with each reaction step: ť A → B → C → D

Suppose the yield is 50% for each reaction, the overall yield of D is only 12.5% from A.
   In a convergent synthesis ť A → B (50%)

   C → D (50%) ť B + D → E (25%)

the overall yield of E (25%) looks much better. Convergent synthesis is applied in the synthesis of complex molecules (see total synthesis) and involve fragment coupling and independent synthesis.
   Examples:

Convergent synthesis is encountered in dendrimer synthesis where branches (with the number of generations preset) are connected to the central core
Proteins of up to 300 amino acids are produced by a convergent approach using chemical ligation.
An example of its use in total synthesis is the final step (photochemical [2+2]cycloaddition) towards the compound Biyouyanagin A : ť

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